Michiel B Haeseker1,2*, Evelien Pijpers3, Nicole HTM Dukers-Muijrers1,2,4, Patty Nelemans5, Christian JPA Hoebe1,2,4, Cathrien A Bruggeman1,2, Annelies Verbon6 and Valère J Goossens1,2

Maximilian von Eynatten1*, Yan Gong2, Angela Emser2 and Hans-Juergen Woerle2

Muhammad M Hammami (Muhammad@kfshrc.edu.sa) Fahad Almogbel (fahd.almogbel@hotmail.com) Sumaya Hammami (sumayahammami@hotmail.com) Jaber Faifi (drfaifi@hotmail.com) Awad Alqahtani (abo-batol-999@hotmail.com) Walid Hashem (abbader@hotmail.com)

Susanne Andersson (susanne.andersson@his.se) Inger Ekman (inger.ekman@gu.se) Febe Friberg (febe.friberg@uis.no) Erik Bøg-Hansen (erik.bog-hansen@vgregion.se) Ulf Lindblad (ulf.lindblad@allmed.gu.se)

Mette Charlot1*, Lars Hougaard Nielsen2, Jesper Lindhardsen1, Ole Ahlehoff1, Anne-Marie S. Olsen1, Morten Lock Hansen1, Peter Riis Hansen1, Jan Kyst Madsen1, Lars Køber3, Gunnar H. Gislason1, and Christian Torp-Pedersen1

YUNSHENG MA, MD, PHD1 RAJI BALASUBRAMANIAN, SCD2 SHERRY L. PAGOTO, PHD1 KRISTIN L. SCHNEIDER, PHD1 ANNIE L. CULVER, BPHARM3 BARBARA OLENDZKI, RD, MPH1 LESLEY TINKER, RD, PHD4 SIMIN LIU, MD, PHD5

MONIKA SAFFORD, MD6 DEIDRE M. SEPAVICH, MS1 MILAGROS C. ROSAL, PHD1 JUDITH K. OCKENE, PHD1 MERCEDES CARNETHON, PHD7 MARTHA ZORN, MS2

JAMES R. HÉBERT, MSPH, SCD8

RYOTARO BOUCHI, MD, PHD1,2 TETSUYA BABAZONO, MD, PHD1,2 MICHINO MUGISHIMA, MD1,2 NAOSHI YOSHIDA, MD1,2

IZUMI NYUMURA, MD1,2 KIWAKO TOYA, MD1,2

KO HANAI, MD, PHD1,2 NOBUE TANAKA, MD, PHD1,2 AKIKO ISHII, MD, PHD1,2 YASUKO UCHIGATA, MD, PHD2 YASUHIKO IWAMOTO, MD, PHD2

COLIN D. JONES, MBBS1 ASEEMA MISRA, MBBS1 RICHARD H. GREENWOOD, MBBS1 MAX O. BACHMANN, MBCHB, PHD2

SOO-KYUNG KIM, MD, PHD1 YOUNG JU CHOI, MD, PHD2 BYUNG WOOK HUH, MD2 CHUL-SIK KIM, MD, PHD3

SEOK WON PARK, MD, PHD1 EUN JIG LEE, MD, PHD4 YONG-WOOK CHO, MD, PHD1 KAP BUM HUH, MD, PHD2

SHANE A. NORRIS, PHD1 CLIVE OSMOND, PHD2 DENISE GIGANTE, PHD3 CHRISTOPHER W. KUZAWA, PHD4 LAKSHMY RAMAKRISHNAN, PHD5 NANETTE R. LEE, PHD6

MANUAL RAMIREZ-ZEA, PHD7 LINDA M. RICHTER, PHD1 ARYEH D. STEIN, PHD8 NIKHIL TANDON, MD9 CAROLINE H.D. FALL, DM2

AND THE COHORTS GROUP*