Omar Lababede , MD ; Moulay Meziane , MD ; and Thomas Rice , MD , FCCP

InMay2007, a 76-year-old nonsmokingwomanwas admitted to
the National Taiwan University Hospital for acute cholecystitis. On
admission, right upper lobe tumor was an incidental finding by chest
radiograph. Chest computed tomography (CT) confirmed a 3.3-cm
solitary tumor at the right upper lobe with nonspecific mediastinal
lymphadenopathies, and CT-guided tumor biopsy revealed adenocarcinoma
with thyroid transcription factor-1 expression. Lung adenocarcinoma
was diagnosed. Contrast-enhanced brain CT

Z Zhang1, E Lanza2, AC Ross1, PS Albert2, NH Colburn2, MJ Rovine3, D Bagshaw1, JS Ulbrecht4
and TJ Hartman1

Toni K. Choueiri, Erica L. Mayer, Youjin Je, Jonathan E. Rosenberg, Paul L. Nguyen, Georges R. Azzi,
Joaquim Bellmunt, Harold J. Burstein, and Fabio A.B. Schutz

Belinda E. Kiely, Yu Yang Soon, Martin H.N. Tattersall, and Martin R. Stockler

Michael F. Press, Guido Sauter, Marc Buyse, Leslie Bernstein, Roberta Guzman, Angela Santiago,
Ivonne E. Villalobos, Wolfgang Eiermann, Tadeusz Pienkowski, Miguel Martin, Nicholas Robert, John Crown,
Valerie Bee, Henry Taupin, Kerry J. Flom, Isabelle Tabah-Fisch, Giovanni Pauletti, Mary-Ann Lindsay,
Alessandro Riva, and Dennis J. Slamon

Tone Hoel Lende, Emiel A.M. Janssen, Einar Gudlaugsson, Feja Voorhorst, Rune Smaaland, Paul van Diest,
Håvard Søiland, and Jan P.A. Baak

Patient 1 is a 65-year-oldwomanwith a diagnosis of breast cancer
metastatic to bone, pleura, pericardium, and lymph nodes. She received
adjuvant chemotherapy with cyclophosphamide, methotrexate,
and fluorouracil following her original diagnosis in 1990. In 1998,
she progressed systemically and was treated with multiple lines of
endocrine therapy. She subsequently received sequential single-agent
chemotherapy with capecitabine, gemcitabine, vinorelbine

Xiaohong R. Yang, Jenny Chang-Claude, Ellen L. Goode, Fergus J. Couch, Heli Nevanlinna, Roger L. Milne, Mia Gaudet, Marjanka K. Schmidt,
Annegien Broeks, Angela Cox, Peter A. Fasching, Rebecca Hein, Amanda B. Spurdle, Fiona Blows, Kristy Driver, Dieter Flesch-Janys, Judith Heinz,
Peter Sinn, Alina Vrieling, Tuomas Heikkinen, Kristiina Aittomäki, Päivi Heikkilä, Carl Blomqvist, Jolanta Lissowska, Beata Peplonska, Stephen Chanock,
Jonine Figueroa, Louise Brinton, Per Hall, Kamila Czene, Keith Humphreys, Hatef Darabi, Jianjun Liu, Laura J. Van ‘t Veer, Flora E. van Leeuwen, Irene
L. Andrulis, Gord Glendon, Julia A. Knight, Anna Marie Mulligan, Frances P. O’Malley, Nayana Weerasooriya, Esther M. John, Matthias W. Beckmann,
Arndt Hartmann, Sebastian B. Weihbrecht, David L. Wachter, Sebastian M. Jud, Christian R. Loehberg, Laura Baglietto, Dallas R. English, Graham G. Giles,
Catriona A. McLean, Gianluca Severi, Diether Lambrechts, Thijs Vandorpe, Caroline Weltens, Robert Paridaens, Ann Smeets, Patrick Neven, Hans Wildiers,
Xianshu Wang, Janet E. Olson, Victoria Cafourek, Zachary Fredericksen, Matthew Kosel, Celine Vachon, Helen E. Cramp, Daniel Connley, Simon S. Cross,
Sabapathy P. Balasubramanian, Malcolm W. R. Reed, Thilo Dörk, Michael Bremer, Andreas Meyer, Johann H. Karstens, Aysun Ay, Tjoung-Won Park-Simon,
Peter Hillemanns, Jose Ignacio Arias Pérez, Primitiva Menéndez Rodríguez, Pilar Zamora, Javier Benítez, Yon-Dschun Ko, Hans-Peter Fischer, Ute Hamann,
Beate Pesch, Thomas Brüning, Christina Justenhoven, Hiltrud Brauch, Diana M. Eccles, William J. Tapper, Sue M. Gerty, Elinor J. Sawyer, Ian P. Tomlinson,
Angela Jones, Michael Kerin, Nicola Miller, Niall McInerney, Hoda Anton-Culver, Argyrios Ziogas, Chen-Yang Shen, Chia-Ni Hsiung, Pei-Ei Wu, Show-
Lin Yang, Jyh-Cherng Yu, Shou-Tung Chen, Giu-Cheng Hsu, Christopher A. Haiman, Brian E. Henderson, Loic Le Marchand, Laurence N. Kolonel,
Annika Lindblom, Sara Margolin, Anna Jakubowska, Jan Lubiński, Tomasz Huzarski, Tomasz Byrski, Bohdan Górski, Jacek Gronwald, Maartje J. Hooning,
Antoinette Hollestelle, Ans M. W. van den Ouweland, Agnes Jager, Mieke Kriege, Madeleine M. A. Tilanus-Linthorst, Margriet Collée, Shan Wang-Gohrke,
Katri Pylkäs, Arja Jukkola-Vuorinen, Kari Mononen, Mervi Grip, Pasi Hirvikoski, Robert Winqvist, Arto Mannermaa, Veli-Matti Kosma, Jaana Kauppinen,
Vesa Kataja, Päivi Auvinen, Ylermi Soini, Reijo Sironen, Stig E. Bojesen, David Dynnes Ørsted, Diljit Kaur-Knudsen, Henrik Flyger, Børge G. Nordestgaard,
Helene Holland, Georgia Chenevix-Trench, Siranoush Manoukian, Monica Barile, Paolo Radice, Susan E. Hankinson, David J. Hunter, Rulla Tamimi,
Suleeporn Sangrajrang, Paul Brennan, James McKay, Fabrice Odefrey, Valerie Gaborieau , Peter Devilee, P.E.A. Huijts, RAEM. Tollenaar, C. Seynaeve, Gillian
S. Dite, Carmel Apicella, John L. Hopper, Fleur Hammet, Helen Tsimiklis, Letitia D. Smith, Melissa C. Southey, Manjeet K. Humphreys, Douglas Easton,
Paul Pharoah, Mark E. Sherman, Montserrat Garcia-Closas

Lisa J. Martin, Qing Li, Olga Melnichouk, Cary Greenberg, Salomon Minkin,
Greg Hislop, and Norman F. Boyd