Manpreet S. Mundi, Maksym V. Karpyak, Christina Koutsari, Susanne B. Votruba,
Peter C. O’Brien, and Michael D. Jensen

Carolina Bruno, Angie D. Fulford, Jenna R. Potts, Ronald McClintock,
RoseMarie Jones, Brenda M. Cacucci, Christine E. Gupta, Munro Peacock,
and Robert V. Considine

Jeffrey M. Testani, MDa,*, Amit V. Khera, BSb, Martin G. St. John Sutton, MBBSa,
Martin G. Keane, MDa, Susan E. Wiegers, MDa, Richard P. Shannon, MDa, and
James N. Kirkpatrick, MDa

Predicting risk does not necessarily prevent it

Beth Unsworth, BSc,a Roberto P. Casula, MD, FRCS, FECTS,b Andreas A. Kyriacou, MBChB, MRCP,a Hemang Yadav, MA, MBBS,a Andrew Chukwuemeka, LLB, MD, FRCS,a Ashok Cherian, MD,b Rex de Lisle Stanbridge, MD, FRCS,b Thanos Athanasiou, MD, PhD, FETCS,a Jamil Mayet, MD, FRCP,a and
Darrel P. Francis, MA, MD, FRCPa Imperial College, and Paddington, London

Imene Tabbi-Anneni1, Robert Cooksey2, Viswanath Gunda1, Shiguo Liu1, Aubrey Mueller1,
5 Guisheng Song1, Donald A. McClain2 and Lee W. Van Eeden1*

Tam K. Dao, PhD,a,b,c Danny Chu, MD,b,d Justin Springer, PhD,b,c Raja R. Gopaldas, MD,e
Deleene S. Menefee, PhD,b,c Thomas Anderson, PhD,b,c Emily Hiatt, BA,a and Quang Nguyen, PhDb,c

Hisato Takagi, MD, PhD, Masafumi Matsui, MD, and Takuya Umemoto, MD, PhD, Shizuoka, Japan

Design and Rationale of the PROTECT Study:
A Placebo-controlled Randomized Study of the Selective A1
Adenosine Receptor Antagonist Rolofylline for Patients
Hospitalized With Acute Decompensated Heart Failure
and Volume Overload to Assess Treatment Effect on
Congestion and Renal Function
BETH DAVISON WEATHERLEY, PhD,1 GAD COTTER, MD,1 HOWARD C. DITTRICH, MD,2 PAUL DELUCCA, PhD,3
GEORGE A. MANSOOR, MD,3 DANIEL M. BLOOMFIELD, MD,3 PIOTR PONIKOWSKI, MD,4
CHRISTOPHER M. O’CONNOR, MD,5 MARCO METRA, MD,6 AND BARRY M. MASSIE, MD,7
FOR THE PROTECT STEERING COMMITTEE, INVESTIGATORS, AND COORDINATORS

ARASH AGHEL, MD,1 KEVIN SHRESTHA, AB,1 WILFRIED MULLENS, MD,3
ALLEN BOROWSKI, RDCS,2 AND W. H. WILSON TANG, MD2