gene polymorphisms on dietary intervention-mediated changes in adiponectin levels and homeostasis

model assessment of insulin resistance (HOMA-IR) indexes.

glucose (IFG) or newly diagnosed type 2 diabetes followed a dietary intervention (replacement

of cooked refined rice with whole grains and an increase in vegetable intake) and regular walking

for 12 weeks without any medication. Adiponectin gene single nucleotide polymorphisms

45TG genotype groups. Subjects with the SNP 45TT genotype showed increased adiponectin

levels and decreased HOMA-IR indexes. Haplotype analysis revealed that homozygous carriers

of the TG haplotype (45TT and 276GG) and heterozygous carriers of the TG haplotype (TG/X)

showed a reduction in the HOMA-IR index after adjustment for baseline levels. Significant

differences were observed in changes in HOMA-IR indexes and adiponectin concentrations

according to the 45-276 TG haplotype in overweight-obese, but not in normal-weight subjects:

the greatest decrease in HOMA-IR indexes and the greatest increase in adiponectin levels were

shown in overweight-obese subjects with the TG/TG haplotype.

insulin resistance indexes in subjects with IFG or newly diagnosed type 2 diabetes in response to

dietary intervention