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C-reactive protein predicts long-term mortality independently of low-density lipoprotein cholesterol in patients undergoing percutaneous cor
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| 07.08.2009, 22:36 |
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Background Few data are available on the association of high-sensitivity C-reactive protein (hs-CRP) and mortality
independent of low-density lipoprotein (LDL) cholesterol in patients undergoing percutaneous coronary intervention (PCI).
Methods Consecutive patients (N = 8,834) undergoing PCI between October 28, 2002, and December 31, 2006, were
followed through June 30, 2007 (average and maximum follow-up of 1.9 and 4.6 years, respectively). High-sensitivity CRP
levels were classified into 4 groups: <1.0, 1.0 to 2.9, 3.0 to 9.9, and ≥10 mg/L.
Results All-cause mortality rates were 14.4, 17.5, 25.7, and 56.4 per 1,000 person-years in patients with hs-CRP levels of
<1.0, 1.0 to 2.9, 3.0 to 9.9, and ≥10 mg/L, respectively. Compared with patients with hs-CRP <1.0 mg/L, the hazard ratios of
mortality after multivariable adjustment, including LDL cholesterol, associated with hs-CRP levels of 1.0 to 2.9, 3.0 to 9.9, and
≥ 10 mg/L were 1.27 (95% CI 0.91-1.75), 1.70 (95% CI 1.26-2.29), and 2.99 (95% CI 2.24-3.99), respectively (P trend <
.001). After multivariable adjustment, trends of higher all-cause mortality at higher hs-CRP were present for patients with LDL
cholesterol <70, 70 to 99, and ≥100 mg/dL (each P < .001). A test for interaction between LDL cholesterol and hs-CRP on allcause
mortality was not significant ( P = .30).
Conclusions High-sensitivity CRP levels provide significant incremental prognostic information for all-cause mortality in
long-term follow-up independent of LDL cholesterol. (Am Heart J 2009;158:277-83.)
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| Категория: Статьи | Добавил: nbylova
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