| Меню сайта |
- Дистанционное образование
|
| Статистика |
Онлайн всего: 1 Гостей: 1 Пользователей: 0 |
|
| СНО терапии |
 |
Relation of Body Mass Index to Mortality After Development of Heart Failure Due to Acute Coronary Syndrome
|
[
]
| 30.06.2009, 11:24 |
Several studies have suggested that obesity may be associated with a survival advantage in
heart failure (HF). The duration of HF likely influences disease severity and may introduce
lead-time bias into analyses of outcomes. The aim of this study was to analyze a cohort in
which the exact time of HF onset could be determined: patients in the University of
Michigan subset of the acute coronary syndromes (ACS) database of the Global Registry of
Acute Coronary Events (GRACE) who developed new-onset HF (no history of HF and left
ventricular ejection fraction <40% or qualitatively diminished) with their index ACS
events from January 1999 to March 2006 (n 446). For analysis, body mass index (BMI)
was categorized as normal (18.5 to <25 kg/m2), overweight (25 to <30 kg/m2), and obese
(>30 kg/m2). Underweight patients (BMI <18.5 kg/m2) were excluded. Separate multivariate
Cox regression models were performed to examine the effect of BMI group and other
potential confounders on all-cause mortality and on the combined outcome of all-cause
death, cardiac transplantation, or ventricular assist device implantation. BMI groups were
not associated with different risks for the combined outcome, although overweight BMI
approached statistical significance for lower risk for the combined outcome. Overweight
BMI was significantly associated with lower risk for all-cause death (hazard ratio 0.63, 95%
confidence interval 0.42 to 0.94, p 0.02), although obese BMI was not (hazard ratio 1.06,
95% confidence interval 0.69 to 1.64, p 0.8). In conclusion, these findings suggest a
U-shaped relation between mortality and BMI in the setting of new-onset HF after
ACS. © 2009 Elsevier Inc. (Am J Cardiol 2009;103:1736 –1740)
|
| Категория: Статьи | Добавил: nbylova
|
| Просмотров: 386 | Загрузок: 0
| Рейтинг: 0.0/0 |
|
Добавлять комментарии могут только зарегистрированные пользователи. [ Регистрация | Вход ] |
|
