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Close adherence to a Mediterranean diet improves endothelial function in subjects with abdominal obesity
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| 22.06.2009, 00:03 |
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ABSTRACT
Background: Abdominal obesity (AO) is associated with increased
risk of cardiovascular disease and type 2 diabetes, whereas the
Mediterranean diet exerts a cardioprotective effect.
Objective: We examined whether a close adherence to aMediterraneanstyle
diet improves endothelial function in individuals with AO.
Design: We recruited 90 subjects with AO without cardiovascular
disease or type 2 diabetes. Participants were randomly assigned to
the intervention or control group. Both groups were instructed to
follow a Mediterranean-style diet for 2 mo. Subjects in the intervention
group additionally had to follow a specific relevant daily
and weekly food plan with close supervision by a dietitian and
provision of basic foods. Flow-mediated dilatation (FMD), lipids,
C-reactive protein (CRP), and insulin resistance with the homeostasis
model assessment (HOMA-IR) were measured.
Results: After 2 mo, subjects in the intervention group increased
their intake of total fat due to higher consumption of monounsaturated
fatty acids as well as intakes of dietary fiber, vitamin C, and
alcohol compared with the control group (all P , 0.05). The intervention
group also increased FMD (2.05%; 95% CI: 0.97,
3.13%), whereas no effect was found in the control group
( 20.32%; 95% CI: 21.31, 0.67%). Changes in lipids and CRP
concentrations did not differ between the 2 groups, whereas diastolic
blood pressure decreased in the intervention group ( 26.44
mm Hg; 95% CI: 28.57, 24.31 mm Hg) compared with the control
group ( 20.76 mm Hg; 95% CI: 22.83, 1.31 mm Hg). Finally, there
was a trend for a reduction in HOMA-IR in the intervention group
compared with the control group ( P = 0.072).
Conclusion: Close adherence to a Mediterranean-style diet
achieved by close dietetic supervision improves endothelial function
in subjects with AO. Am J Clin Nutr 2009;90:1–6.
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| Категория: Статьи | Добавил: nbylova
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