| Меню сайта |
- Дистанционное образование
|
| Статистика |
Онлайн всего: 1 Гостей: 1 Пользователей: 0 |
|
| СНО терапии |
 |
Comparison of Ischemic Side Effects of Levosimendan and Dobutamine with Levosimendan and Dobutamine with
|
[
]
| 21.06.2009, 20:58 |
|
Background: Levosimendan improves cardiac contractility without increasing oxygen consumption. However,
its effects on ischemia were not supported with the utilization of a noninvasive parameter of myocardial
characterization.
Hypothesis: The changes observed in integrated backscatter (IBS) may be reflective of change in myocardial
ischemia. In this study, the effect of levosimendan on ischemia detected by IBS was evaluated in patients with
ischemic heart failure (HF).
Methods: Patients who had LVEF <40% and NYHA III–IV symptoms of HF were included in this study.
Patients were randomized to levosimendan (n = 21), or to dobutamine (n = 25) groups. The cyclic variation of
integrated backscatter (CVIBS) was determined as the difference between the maximal and minimal values in
a cardiac cycle, average of three consecutive beats. CVIBS was taken from the mid-anteroseptal, mid-inferior,
and mid-posterolateral areas of the parasternal short axis images before the drug administration and at the
end of the 24-hour infusion period.
Results: Baseline characteristics and concomitant medications were similar in both groups. A significant
reduction in CVIBS was detected in anteroseptal (7 .6 1.4 dB versus 5.9 0.8 dB, p = 0.01), inferior wall
(7 .4 0.8 dB versus 6.7 1.5 dB, p = 0.03), and posterolateral wall (9.0 1.2 dB versus 8.2 0.6 dB,
p = 0.04) after dobutamine administration, while no significant changes were observed in the levosimendan
group in all walls.
Conclusions: Unlike dobutamine, levosimendan may not induce myocardial ischemia as shown by CVIBS at
commonly used dosages in the setting of decompensated HF without active ischemia.
|
| Категория: Статьи | Добавил: nbylova
|
| Просмотров: 413 | Загрузок: 0
| Рейтинг: 0.0/0 |
|
Добавлять комментарии могут только зарегистрированные пользователи. [ Регистрация | Вход ] |
|
