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Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adult
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| 21.06.2009, 20:47 |
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ABSTRACT
Background: Rodent studies show that oligofructose promotes
weight loss, stimulates satiety hormone secretion, reduces energy intake,
and improves lipid profiles.
Objective: Our objective was to examine the effects of oligofructose
supplementation on body weight and satiety hormone concentrations
in overweight and obese adults.
Design: This study was a randomized, double-blind, placebocontrolled
trial. Forty-eight otherwise healthy adults with a body mass
index (in kg/m 2) . 25 were randomly assigned to receive 21 g oligofructose/
d or a placebo (maltodextrin) for 12 wk. Body composition
(by dual-energy X-ray absorptiometry); meal tolerance tests, including
satiety hormone response; food intake; and subjective appetite
ratings were determined.
Results: There was a reduction in body weight of 1.0360.43 kg with
oligofructose supplementation, whereas the control group experienced
an increase in body weight of 0.45 6 0.31 kg over 12 wk
( P ј 0.01). A lower area under the curve (AUC) for ghrelin
( P ј 0.004) and a higher AUC for peptide YY (PYY) with oligofructose
( P ј 0.03) coincided with a reduction in self-reported caloric
intake ( P 0.05). Glucose decreased in the oligofructose group and
increased in the control group between initial and final tests
( P 0.05). Insulin concentrations mirrored this pattern (P 0.05).
Oligofructose supplementation did not affect plasma active glucagonlike
peptide 1 secretion. According to a visual analog scale designed
to assess side effects, oligofructose was well tolerated.
Conclusions: Independent of other lifestyle changes, oligofructose
supplementation has the potential to promote weight loss and improve
glucose regulation in overweight adults. Suppressed ghrelin and enhanced
PYY may contribute in part to the reduction in energy intake.
The trial was registered at clinicaltrials.gov as NCT00522353. Am
J Clin Nutr 2009;89:1751–9.
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| Категория: Статьи | Добавил: nbylova
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