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Adipocyte fatty acid binding protein during refeeding of female patients with anorexia nervosa
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| 23.05.2009, 00:15 |
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Abstract
Background Adipocyte fatty acid binding protein
(A-FABP) has been suggested to play an important role in
fat metabolism linking obesity and the metabolic syndrome.
Increasing A-FABP plasma levels were observed
during greatest weight loss after bariatric surgery suggesting
that A-FABP may indicate changes in fat mass in
dynamic situations.
Aim of the study As there are no data on weight gain, we
investigated the effect of refeeding anorexic patients on
body composition and A-FABP plasma levels.
Methods Parameters of glucose and lipid metabolism as
well as plasma levels of leptin and A-FABP were prospectively
assessed in 16 female patients with anorexia
nervosa during inpatient weight restoration. Body composition
was determined by multifrequency body impedance
analysis.
Results After 28 days, fat mass increased from
4.4 ± 2.5 kg at baseline to 5.5 ± 2.2 kg (P\0.01), constituting
40% of total weight gain. Conversely, A-FABP
concentrations decreased from 32.56 ± 35.59 ng/ml at
baseline to 21.27 ± 13.68 ng/ml (P\0.05), which corresponds
to a significant decrease in the proportion of
A-FABP per kilogram fat mass from 7.86 ± 5.23 to
4.09 ± 2.12 ng/ml/kg (P B 0.001). Variation in A-FABP
plasma concentration was predictive for changes in total
cholesterol levels (adjusted r2 = 0.239; P B 0.05), but not
for gain in weight, fat mass, or percent body fat.
Conclusion The present results indicate that variation in
A-FABP plasma levels reflect alterations in nutritional
status in patients with anorexia nervosa.
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| Категория: Статьи | Добавил: nbylova
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