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Circulating angiotensin II is associated with body fat accumulation and accumulation and
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| 09.05.2009, 14:09 |
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Abstract
Adipocytes express all components of the renin-angiotensin system, and the renin-angiotensin system is involved in obesity and insulin
resistance. Circulating angiotensin II (Ang II) is detectable in blood, but its significance in human obesity remains unknown. The aim of this
study was to investigate plasma Ang II in obese patients with type 2 diabetes mellitus (T2D) and the change during weight loss. Fifty
Japanese obese subjects with T2D (body weight, 75.0 ± 14.1 kg; body mass index, 29.1 ± 3.7 kg/m 2; visceral fat area [VFA], 169.3 ±
54.3 cm 2; hemoglobin A1c, 7.6% ± 1.5%) were enrolled. The subjects were prescribed a diet of daily caloric intake of 20 kcal/kg for
24 weeks. Plasma Ang II was measured by radioimmunoassay. Leptin, adiponectin, and lipoprotein lipase mass in preheparin serum were
also measured as adipocyte-derived factors. After 24 weeks of weight reduction diet, the mean body weight, VFA, and hemoglobin A 1c
decreased significantly by 2.3%, 7.0%, and 8.3%, respectively. The mean plasma Ang II decreased by 24% ( P b .0001) and correlated with
body weight both at baseline ( r = 0.425, P = .0018) and at 24 weeks (r = 0.332, P = .0181). The change in Ang II correlated with changes in
body weight ( r = 0.335, P = .0167) and VFA (r = 0.329, P = .0191). The change in Ang II also correlated positively with change in leptin
( r = 0.348, P = .0127) and tended to correlate negatively with change in lipoprotein lipase mass in preheparin serum (r = −0.260, P = .0683),
which is a marker of insulin sensitivity. Plasma Ang II is associated with body weight, decreases during weight loss, and is associated with
markers of insulin resistance in obese subjects with T2D.
© 2009 Published by Elsevier Inc.
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| Категория: Статьи | Добавил: nbylova
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