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The effects of electrical stimulation or an electrolytic lesion in the mediodorsal thalamus of the rat on survival, body weight, food intake
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| 03.05.2009, 15:02 |
The glucose metabolism in the mediodorsal thalamus (MD) is increased in rats in the activity-based
anorexia (ABA) model. In patients, electrical stimulation in hyperactive brain regions reduced symptoms
in e.g. major depressive disorder and cluster headache. In two blinded randomised controlled experiments,
we therefore examined the effects of high-frequency electrical stimulation and an electrolytic
lesion in the MD in a validated rat model for anorexia nervosa. The ABA model was successfully replicated
in all our experiments, with a reduction in body weight, food intake, and survival time and an
increase in running activity.
In a first experiment, we evaluated the effect of electrical stimulation or a curative lesion in the MD
on survival, body weight, food intake and locomotor activity in ABA rats. Electrical MD stimulation or
an electrolytic MD lesion did not improve the symptoms of rats in the ABA model, compared to control
groups.
In a second experiment, we investigated the effect of a preventive electrolytic lesion in the MD on rats
in the ABA model. Although there was no significant improvement of survival, body weight and food
intake, locomotor activity was significantly reduced in the lesion group compared to the control group.
Apart from this positive effect on running activity, we found no convincing evidence for the suitability
of the MD as a neuromodulation target for anorexia nervosa patients.
© 2009 Elsevier Inc. All rights reserved.
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| Категория: Статьи | Добавил: nbylova
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