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Prognostic Significance of Ankle-Brachial Index, Brachial-Ankle Pulse Wave Velocity, Flow-Mediated Dilation, and Nitroglycerin-Mediated Dila
[ ] 09.03.2009, 22:12

Background: Identifying patients at high risk of cardiovascular

disease is important in managing patients undergoing

hemodialysis. Methods: We evaluated a series of prognostic

values: flow-mediated dilation (FMD) and nitrogen-mediated

dilation (NMD), an index of endothelium-dependent and

endothelium-independent function, respectively, anklebrachial

index (ABI), and brachial-ankle pulse wave velocity

(baPWV) in patients undergoing chronic hemodialysis. Results:

A cohort of 199 patients was studied. At entry, these

values were examined and the prognostic significances

were investigated. In estimating the significance of baPWV,

patients with ABI ! 0.9 were excluded. During the follow-up

period, 24 deaths occurred including 14 cardiovascular and

10 noncardiovascular fatal events. Overall, the survival rates

were significantly lower in the low ABI than in the high ABI

group, but the survival rates were not significantly different

between the high and low FMD, NMD, or baPWV groups.

Cardiovascular survival rates were significantly lower in the

low ABI than in the high ABI group, and in the high baPWV.

Background: Identifying patients at high risk of cardiovascular

disease is important in managing patients undergoing

hemodialysis. Methods: We evaluated a series of prognostic

values: flow-mediated dilation (FMD) and nitrogen-mediated

dilation (NMD), an index of endothelium-dependent and

endothelium-independent function, respectively, anklebrachial

index (ABI), and brachial-ankle pulse wave velocity

(baPWV) in patients undergoing chronic hemodialysis. Results:

A cohort of 199 patients was studied. At entry, these

values were examined and the prognostic significances

were investigated. In estimating the significance of baPWV,

patients with ABI ! 0.9 were excluded. During the follow-up

period, 24 deaths occurred including 14 cardiovascular and

10 noncardiovascular fatal events. Overall, the survival rates

were significantly lower in the low ABI than in the high ABI

group, but the survival rates were not significantly different

between the high and low FMD, NMD, or baPWV groups.

Cardiovascular survival rates were significantly lower in the

low ABI than in the high ABI group, and in the high baPWV.

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