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Resistin, Adiponectin, and Risk of Heart Failure
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| 09.03.2009, 15:48 |
Objectives We tested the association of the adipokines resistin and adiponectin with incident heart failure.
Background Abnormal concentrations of adipokines may partially explain the association between obesity and heart failure.
Methods We related circulating adipokine concentrations to the incidence of heart failure in 2,739 participants in the Framingham
Offspring Study.
Results During 6 years of follow-up, 58 participants developed new-onset heart failure. In proportional hazards models
(adjusting for age, sex, blood pressure, antihypertensive treatment, diabetes, smoking, total/high-density lipoprotein
cholesterol ratio, prevalent coronary heart disease, valvular heart disease, left ventricular hypertrophy, and
estimated glomerular filtration rate) using the lowest third of the resistin distribution as the referent, the hazard
ratios for heart failure in the middle and top thirds were 2.89 (95% confidence interval [CI]: 1.05 to 7.92) and
4.01 (95% CI: 1.52 to 10.57), respectively (p 0.004 for trend). Additional adjustment for body mass index,
insulin resistance (measured with the homeostasis model), C-reactive protein, and B-type natriuretic peptide did
not substantively weaken this association (multivariable hazard ratios [HRs]: 2.62 and 3.74, p 0.007). In the
maximally adjusted model, each SD increment in resistin (7.45 ng/ml) was associated with a 26% increase in
heart failure risk (95% CI: 1% to 60%). Concentrations of adiponectin were not associated with heart failure
(multivariable HRs: 0.87 and 0.97, p 0.9).
Conclusions Increased circulating concentrations of resistin were associated with incident heart failure, even after accounting
for prevalent coronary heart disease, obesity, and measures of insulin resistance and inflammation. The findings
suggest a role for resistin in human disease and a novel pathway to heart failure. (J Am Coll Cardiol 2009;53:
754–62) © 2009 by the American College of Cardiology Foundation
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| Категория: Статьи | Добавил: nbylova
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