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Will the Universal Definition of Myocardial Infarction Criteria Result in an Overdiagnosis of Myocardial Infarction?
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| 09.03.2009, 15:13 |
The Universal Definition of Myocardial Infarction (acute myocardial infarction [AMI])
requires detection of increasing or decreasing cardiac biomarkers (preferably cardiac
troponin) with >1 value >99th percentile, together with either clinical symptoms, new
ischemic electrocardiographic changes, or typical imaging findings indicative of myocardial
necrosis as diagnostic criteria for AMI. However, a small cardiac troponin elevation
together with ST-T segment abnormalities may also occur in clinically stable populations.
Accordingly, 0.6% of elderly subjects from a community sample (PIVUS Study) and 6.7%
of patients stabilized after an acute coronary syndrome (FRISC II Study) would have been
labeled AMI following the Universal Definition of AMI when diagnostic classification had
been based on a single cardiac troponin I result. In conclusion, our results emphasized the
importance of a significant change in cardiac troponin to avoid misdiagnosis of
AMI. © 2009 Elsevier Inc. (Am J Cardiol 2009;103:588 –591
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| Категория: Статьи | Добавил: nbylova
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